BETASONE -N E/E DROPS

Eye/Ear Drops

BETASONE -N E/E DROPS

PACKING:
576x10ml

COMPOSITION:
Betamethasone Sodium Phosphate
I.P.
0.1% w/v
Neomycin Sulphate
I.P.
0.5% w/v
Benzalkonium Chloride solution
I.P.   
0.02% v/v
(Preservative)
 
 
Sterile Aqueous Buffered Vehicle    
 
q.s.
 
DESCRIPTION:
Betamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Neomycin is an aminoglycoside antibiotic which binds to four nucleotides of 16S rRNA and a single amino acid of protein S12.
 
MECHANISM OF ACTION:
Betamethasone is a glucocorticoid receptor agonist. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Neomycin interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit.
 
INDICATIONS:
This medication treats only bacterial eye and ear infections.
 
CONTRA-INDICATIONS:
Contraindicated in patients who are hypersensitive to any ingredient of this product.
 
SIDE EFFECTS:
Stomach upset, headache, dizziness, trouble sleeping, increased appetite, Nausea, vomiting, and diarrhea may occur.
 
DRUG INTERACTIONS:
Other medications that may affect the hearing or hearing loss if taken with neomycin. Some examples include: amikacin, tobramycin, amphotericin B, cidofovir, cisplatin, polymyxin B, cephalosporins such as cephaloridine, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, among others.
 
WARNINGS:
Before using this medication, tell your doctor or pharmacist your medical history, especially of: hearing problems (including deafness, decreased hearing), intestinal problems (including blockage, swelling, ulcers), kidney problems, myasthenia gravisParkinson's disease.
 
DOSAGE:
As directed by the physician.
 
DIRECTIONS:
Use the solution within one month after opening the container.
Do not use if the solution contains particles/suspended matter.
 
STORAGE:
Store in a cool, dry place. Protect from light.
 
PRESENTATION: 10ml plastic vial
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