KOFF GO PLUS TABLETS

KOFF GO PLUS TABLETS

PACKING:
60x20x10 tablets

COMPOSITION:
Each uncoated tablet contains:
Levocetirizine Dihydrochloride          
I.P.          
5 mg
Phenylephrine Hydrochloride
I.P.
5 mg
Ambroxol Hydrochloride
I.P.
30 mg
Paracetamol
I.P.
325mg
Excipients
 
q.s.

DESCRIPTION:
Levocetirizine Dihydrochloride is a third-generation non-sedative antihistamine, active enantiomer of Cetirizine. Phenylephrine Hydrochloride is a selective α1-adrenergic receptor agonist used primarily as a decongestant. Ambroxol Hydrochloride is the metabolite of bromhexine and a mucolytic agent. Ambroxol acts as secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. Paracetamol is a para-aminophenol derivative,
 
MECHANISM OF ACTION:
Levocetirizine works by blocking histamine receptors. It does not prevent the actual release of histamine from mast cells, but prevents it binding to its receptors. Phenylephrine constricts the blood vessels in the nasal mucous membranes and allows the air passages to open up. The majority of the sympathomimetic action is due to direct stimulation of the adrenoceptors. Ambroxol facilitates mucociliary clearance by intensifying the motion of the cilia present on the ciliated respiratory epithelium. Paracetamol produces antipyresis by acting on the hypothalamic heat regulating center and analgesia by elevating the pain threshold.
 
INDICATIONS:
Seasonal/allergic rhinitis, nasal discomfort, body ache, stubborn cough.
 
CONTRA-INDICATIONS:
There are no absolute contraindications but in patients with gastric ulceration relative caution should be observed. Use cautiously in pregnancy & lactation.
 
SIDE-EFFECTS:
Drowsiness, dry mouth, sore throat, tiredness.
 
DOSAGE:
As directed by the physician.

PRECAUTIONS:

Overdosage of Paracetamol may cause liver damage.
 
STORAGE:
Store in a cool, dry and dry place.
 
PRESENTATION: 20x10 tablets in a cardboard carton

 

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