SERAGESIC TABLETS

Tablets

SERAGESIC TABLETS

PACKING:
54x10x10 tablets

COMPOSITION:
Each film coated tablet contains:
Paracetamol
I.P.
325 mg
Diclofenac Potassium
B.P.     
50 mg
Serratiopeptidase (enteric coated)     
I.P.
15 mg
 
CLINICAL PHARMACOLOGY:
Serratiopeptidase: Anti-inflammatory, antioedemic and fibrinolytic activity and acts rapidly on localized inflammation. It binds to α2 macroglobulin in the blood in a 1:1 ratio. This helps to mask its antigenicity but retains its enzymatic activity. Levels of serratiopeptidase are slowly transferred to the exudates at the site of infection and inflammation and gradually blood levels decline.
 
Paracetamol: Paracetamol is a non-steroidal antiinflammatory drug and is a paraaminophenol derivative. It is centrally acting analgesic and a potent antipyretic, but devoid of a significant antiinflammatory effect which could be due to its weak activity on peripheral prostaglandin synthetase.
 
Diclofenac potassium: Diclofenac potassium is a non-steroidal anti-inflammatory, analgesic and antipyretic drug, which inhibits prostaglandin synthesis by interfering with the action of prostaglandin synthetase. It is ideally suited for patients on sodium free diet, hypertensive patients and those on diuretic therapy.
 
INDICATIONS:
Inflammatory edema and swelling, muscular and skeletal pain.
 
CONTRAINDICATIONS:
Hypersensitivity to the ingredients. Blood coagulation abnormalities, peptic ulcer.
 
SPECIAL PRECAUTIONS:
Patient having a history GI ulceration, hematemesis, severe cardiac, hepatic and renal impairment or insufficiency, Patient undergoing treatment with anticoagulants.
 
ADVERSE EFFECTS:
Gastrointestinal disturbances such as nausea and gastric discomforts.
 
DRUG INTERACTIONS:
Paracetamol enhances oral anticoagulant activity. Chronic use of alcohol potentiates hepatotoxicity.
 
DOSAGE:
As prescribed by the physician.
 
STORAGE:
Keep in a cool and dry place.
 
PRESENTATION:    10x10 tablets in a cardboard carton
 
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