Ofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone. Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.
MECHANISM OF ACTION:
It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, which is an enzyme necessary to separate replicated DNA, thereby inhibiting bacterial cell division.
It is used to treat a variety of bacterial infections. It works by stopping the growth of bacteria.
This antibiotic treats only bacterial infections.
Ofloxacin is considered to be contraindicated for the treatment of certain sexually transmitted diseases due to bacterial resistance. Caution in patients with liver disease. Ofloxacin is also considered to be contraindicated within the pediatric population, pregnancy, nursing mothers, patients with psychiatric illnesses and in patients with epilepsy or other seizure disorders.
Upset stomach, nausea, diarrhea, headache, dizziness, lightheadedness, or trouble sleeping may occur. A very serious allergic reaction to this drug is rare.
Corticosteroids, duloxetine, drugs to treat diabetes (e.g., glyburide, insulin), nonsteroidal anti-inflammatory drugs (NSAIDs such as ibuprofen, naproxen), probenecid, theophylline, warfarin.
As directed by the physician.
Store in a cool, dry place. Protect from light.
PRESENTATION: 30ml bottle