PERIDON DROPS

PERIDON DROPS

PACKING:
144x30ml

COMPOSITION:
Each ml contains:
Domperidone          
B.P.
1mg
 
DESCRIPTION::
Domperidone is a dopamine antagonist (blocking both D1 & D2 receptors) which is structurally related to the benzimidazole. Domperidone is a potent gastrokinetic agent.
 
MECHANISM OF ACTION::
Domperidone facilitates gastrointestinal smooth muscle activity by inhibiting dopamine at the D1 receptors and inhibiting the release of neural acetylcholine by blocking D2 receptors. It decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. The antiemetic properties are related to its dopamine receptor-blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which regulates nausea and vomiting.
 
INDICATIONS:
Treatment of nausea and vomiting of various origins including infectious, dietetic origin, or induced by radiotherapy and slowed movement in the gastrointestinal tract.
 
CONTRAINDICATIONS:
Known hypersensitivity to domperidone or any of the excipients, In patients with moderate or severe hepatic impairment.
 
SIDE EFFECTS:
Headache, dizziness, dry mouth, nervousness, flushing, or irritability may occur the first several days as your body adjusts to the medication.
 
PRECAUTIONS:
Shake well before use. Avoid over medication.
 
DOSAGE:
As directed by the physician.
 
STORAGE:
Store in a cool and dry place, Protect from direct sunlight.
 
PRESENTATION:   30ml bottle with dropper
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