XTRADERM CREAM

External Preparations

XTRADERM CREAM

PACKING:
432x10g

COMPOSITION:
 
Clobetasol Propionate
I.P.
  0.05% w/w
Neomycin Sulphate
I.P.
  0.5% w/w
Miconazole Nitrate
I.P.
  2% w/w
Chlorocresol (as preservative)   
I.P.
  0.1% w/w
In a Cream base
 
  q.s.
 
DESCRIPTION:
Xtraderm cream contains three active ingredients Clobetasol Propionate, Neomycin Sulphate and Miconazole Nitrate. Clobetasol Propionate is a type of medicine called a topical corticosteroid. Neomycin Sulphate is an aminoglycoside antibiotic and is used to treat bacterial infections. Miconazole Nitrate is an imidazole anti fungal agent.
 
 
MECHANISM OF ACTION:
Clobetasol Propionate controls the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Neomycin Sulphate binds to a specific receptor protein on the 30S subunit of bacterial ribosomes, and interferes with an initiation complex between mRNA (messenger RNA) and the 30S subunit, inhibiting protein synthesis. Miconazole Nitrate interacts with 14-? demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents.
 
INDICATIONS:
Used to treat severe inflammatory skin disorders such as eczema, dermatitis or psoriasis that are infected or likely to become infected.
 
CONTRAINDICATIONS:
Hypersensitivity to any of the ingredients of this medicine and children under two year old.
 
SIDE-EFFECTS:
Thinning of the skin, changes in skin pigmentation, stretch marks (striae).
 
DIRECTIONS FOR USE:
Apply thinly and evenly on the affected area of the skin.
 
STORAGE:
Do not freeze. Store in a cool, dry and dark place.
 
PRESENTATION: 10g tube
 
SHAKE WELL BEFORE USE
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