ORTHOMAC GEL

External Preparations

ORTHOMAC GEL

PACKING:
12x30g

COMPOSITION:
Diclofenac diethylamine
I.P.
  1.16% w/w
Equ. To Diclofenac Sodium
 
1% w/w
Linseed oil
B.P.
   3% w/w
Methyl Salicylate
I.P.
   10% w/w
Menthol
I.P.
   5% w/w
Benzyl Alcohol
I.P.
   1% w/w
(As Preservative)
 
 
In a gel base
 
q.s.
 
DESCRIPTION:
Orthomac gel contains Diclofenac diethylamine that is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Linseed oil is rich in alpha-linolenic acid (ALA). ALA belongs to group of substance called omega-3 fatty acid which helps to reduce inflammation. Methyl Salicylate act as a counter rubefacient by stimulating the superficial afferent nerves from same spinal segments that supply the painful muscles. Menthol has some local anesthetic and counterirritant qualities and also acts as a weak kappa opioid receptor agonist making it an analgesic as well.
 
MECHANISM OF ACTION:
Diclofenac acts by reducing the inflammation by inhibiting the COX-isoenzyme and thereby decreasing the synthesis of proinflammatory prostaglandins. At high tissue concentration Diclofenac appears to have the capacity to act as a sodium channel blocker to mediate local-anesthetic like effects on nociceptive afferent fibers. Linseed oil helps to reduce inflammation by distinct phases, firstly an acute phase of local vasodilatation and increased capillary permeability. Methyl Salicylate topically used to cause dilation of the capillaries thereby increasing blood flow to the area. Menthol has ability to chemically trigger the cold-sensitive TRPM8 receptors in the skin is responsible for its cooling sensation when applied to the skin. It enhances the efficacy of other topical applications by increasing penetration via vasodilation.
 
INDICATIONS:
Sprain, Backache, Muscular pain, Soft tissue injuries, Musculoskeletal disorders.
 
CONTRAINDICATIONS:
Contraindicated in patients with known hypersensitivity to diclofenac or any components of the drug product.
 
ADVERSE EVENTS:
Local skin reactions, Hypersensitivity reactions.
 
STORAGE:
Store in a cool & dry place. Do not freeze.
 
DOSAGE:
As directed by physician.
 
PRESENTATION:
30 g tube
 
FOR EXTERNAL USE ONLY
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