ITROMAC-200 CAPSULE

Capsules

ITROMAC-200 CAPSULE

PACKING:
1x4 Capsules

COMPOSITION:

Each hard gelatin capsule contains

Itraconazole Pellets
 
 
Eq. to Itraconazole
B.P.
200 mg
Excipients
 
q.s.
Approved colours used in empty Capsule shell.
 
 
 
DESCRIPTION:
The triazoles are first-line agents for the prevention and treatment of invasive allergic fungal infections. Triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.
 
MECHANISM OF ACTION:
Itraconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Itraconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
 
INDICATIONS:
For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extra pulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
 
DOSAGE:
As directed by the physician.
 
CONTRA-INDICATIONS:
Contraindicated in patients who have shown hypersensitivity to Itraconazole or the excipients.
 
SIDE EFFECTS:
Headache, Dizziness, Nausea, Vomiting, Upset Stomach, Constipation and Muscle aches.
 
STORAGE:
Store in a cool and dry place. Protect from light.
 
PRESENTATION:
10x1x4 Capsules in a cardboard carton.
 
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