RABILITE-DSR CAPSULE

Capsules

RABILITE-DSR CAPSULE

PACKING:
60x10x10 Capsules

COMPOSITION:
Each capsule contains:
Rabeprazole Sodium
I.P.
20 mg
(as enteric coated pellets)
 
 
Domperidone
I.P.
30 mg
(as sustained release pellets)
 
 
Excipients
 
q.s.
 
DESCRIPTION:
Rabeprazole is called a proton pump inhibitor or an “acid pump inhibitor”. Domperidone which is an antiemetic and prokinetic agent.
 
MECHANISM OF ACTION:
Rabeprazole sodium belongs to the class of anti-secretory compounds, the substituted benzimidazoles, which do not exhibit anticholinergic or H2 histamine antagonist properties, but suppress gastric acid secretion by the specific inhibition of the H+/K+-ATPase enzyme (the acid or proton pump). The effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus. Rabeprazole is converted to the active sulphenamide form through protonation and it subsequently reacts with the available cysteines on the proton pump. Domperidone is a dopamine antagonist with anti-emetic properties. Domperidone is a peripheral dopamine D2-receptor antagonist, which regulates the motility of gastric and small intestinal smooth muscle. Antiemetic activity is due to the blockade of dopamine receptors in the chemoreceptor trigger zone.
 
INDICATIONS:
Used for hyperacidity, dyspepsia, gastro-oesophageal reflux disease.
 
CONTRAINDICATIONS:
Contraindicated in patients with rise in prolactin level and hypersensitivity.
 
SIDE EFFECTS:
Headache, diarrhoea, skin rash, itching, diarrhoea, abdominal pain, constipation.
 
DOSAGE:
As directed by the physician.
 
STORAGE:
Store in a cool & dry place. Protect from light.
 
PRESENTATION:
10 x 10 capsules in a unit carton
 
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