PANTOMAC INJECTION

PANTOMAC INJECTION

PACKING:
22x6x40mg vial

COMPOSITION:
Part I each vial contains:
Pantoprazole Sodium          
I.P.
40mg
Equi. to Pantoprazole
 
Part II
 
 
Sodium Chloride
I.P.
10ml
 
DESCRIPTION::
Pantoprazole Sodium is a substituted benzimidazole, sodium 5-(difluoromethoxy)-2-[(3, 4-dimethoxy-2-pyridinyl) methyl) sulfinyl]-1H benzimidazole, a compound that inhibits gastric acid secretion.
 
MECHANISM OF ACTION:
Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by covalently binding to the (H+, K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus. The binding to the (H+, K+)-ATPase results in a duration of antisecretory effect that persists longer than 24 hours for all doses tested.
 
INDICATIONS:
Indicated for the treatment of moderate and severe reflux esophagitis.
 
DOSAGE AND ADMINISTRATION:
As directed by the physician. For slow IV use only.
 
DIRECTION FOR RECONSTITUTION:
The content of the vial needs to be reconstituted with 10 ml of Sodium Chloride Injection BP 0.9% w/v before injection.
This freshly prepared solution should be administered intravenously over 2 to 15 minutes, either as a slow injection or it may be further diluted with 100 ml of sodium chloride injection BP 0.9 % w/v or 5% glucose injection and administered as a short term infusion. The reconstituted solution must be used within 12 hours of preparation.
 
SIDE EFFECTS:
Headache, diarrhea, abdominal pain, flatulence, constipation, allergic reactions such as skin rash and pruritus may occur.
 
CONTRAINDICATIONS:
Contra indicated in patients with known hypersensitivity to the formulation.
 
STORAGE:
Store in a cool place, Protect from direct sunlight.
 
PRESENTATION:   One 10 ml vial with 10 ml Sodium Chloride ampoule
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