TRIXONE PLUS INJECTION

TRIXONE PLUS INJECTION

PACKING:
12x12x1.5g vial

COMPOSITION:
Each vial contains:
Part I
 
Ceftriaxone Sodium Sterile          
U.S.P
1g
equi. to Ceftriaxone
 
 
Salbactum Sodium
U.S.P
500mg
equi. to Salbactum
 
 
Part II
 
Water for Injection
B.P.
10ml
 
DESCRIPTION::
Trixone Plus Injection is a combination of a beta-lactam antibiotic- Ceftriaxone with an inhibitor of beta lactamase-Sulbactam sodium, giving a highly powerful antibacterial formulation. ?Ceftriaxone is a third generation cephalosporin antibiotic, Sulbactam sodium is a derivative of the basic penicillin nucleus.
 

 

MECHANISM OF ACTION:
Ceftriaxone inhibits the third and final stage of bacterial cell wall synthesis by preferentially binding to the specific PBPs located inside the bacterial cell wall. Ceftriaxone interferes with PBP-mediated cell wall synthesis leading to cell lysis and death. Sulbactam, by irreversibly binding to the beta-lactamases produced by the bacteria protects the beta-lactam ring of ceftriaxone, and conserves the activity. The combination helps extend its utility in the treatment of broad range of infections caused by organisms resistant to the antibiotic alone.
 
INDICATIONS:
Renal and urinary tract infections, skin and soft tissue infections, infections in dialysis unit.
 
CONTRAINDICATIONS:
Contraindicated in patients with known allergy to cephalosporin group of antibiotics. Hypersensitivity to penicillin may pre-dispose the patient to the possibility of allergic cross-reactions.
 
SIDE EFFECTS:
Diarrhoea, nausea & vomiting, headache, dizziness, increase in serum creatinine.
 
DOSAGE:
As prescribed by the physician.
 
STORAGE:
Store in a single dose container in the frozen state.
 
FOR IM/IV USE ONLY
 
PRESENTATION:   1.5gm vial
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