Piperazine is an anthelminthic (that expels parasitic worms (helminths) from the body ). It is especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine Hydrate and Piperazine Citrate are the main anthelminthic piperazines.
equivalent to Piperazine Hexahydrate
MECHANISM OF ACTION:
Piperazine is a GABA receptor agonist. Piperazine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.
Piperazine is indicated as an alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm).
Hypersensitivity reactions to piperazine and its salts.
The blurring of vision (in rare cases), hypersensitivity (fever, joint pain, skin rash or itching).
Phenothiazines, high doses of piperazine may enhance the effects of phenothiazines, such as chlorpromazine, and increase the risk of seizures; concurrent use is not recommended.
PRECAUTIONS & WARNING:
Regular visits to the physician to check progress, checking with the physician if no improvement after the full course of treatment or if symptoms persist.
As prescribed by the physician.
Store in a cool & dark place.
SHAKE WELL BEFORE USE