Description: Scabisin lotion is a topical medication used for the treatment of scabies and other parasitic skin infestations due to its insecticidal properties.
Dosage Form: Lotion
Route of Administration: Topical
Composition:
Gamma Benzene Hexachloride I.P. 1% w/v
Emulsion base q.s.
Mechanism of Action: Gamma Benzene Hexachloride (Lindane) is an organochlorine insecticide that used as a pediculicide and a scabicide. It exerts its parasiticidal action by being directly absorbed through the parasite's exoskeleton (primarily lice, or scabies) and their ova. The gamma-aminobutyric acid (GABA) receptor/chloride ionophore complex is the primary site of action. Blockage of the GABA-gated chloride channel reduces neuronal inhibition, which leads to hyperexcitation of the central nervous system. This results in paralysis, convulsions, and death. Lindane has very low ovicidal activity.
Indications: Scabisin lotion is used to treat scabies and pediculosis.
Dosage: As directed by the physician.
Side effects: Burning, Itching, Redness and Skin dryness or Erythema.
Contraindications: Patients with a history of hypersensitivity or allergic reactions to Lindane should avoid its use.
Precautions: Lindane can be neurotoxic, and excessive use or improper application may lead to neurotoxic effects. It should be used cautiously, especially in infants, young children, and individuals with a history of seizures or compromised neurological function. Limit the duration of use and avoid prolonged or repeated applications to minimise the risk of systemic absorption and potential adverse effects. Do not apply lindane to broken or irritated skin, as it may enhance systemic absorption. Lindane is contraindicated in certain populations, including pregnant or breastfeeding women, individuals with a history of seizures, and those with compromised skin integrity. Use caution in infants and young children due to their increased susceptibility to toxicity.
Storage: Store at a temperature not exceeding 25 °C. Do not freeze.
Presentation: 100ml bottle