Description: Torformin 1000 SR Tablets contains Metformin, a biguanide with antihyperglycaemic effects, lowering both basal and postprandial plasma glucose. Pharmaceutical Dosage Form: Tablet Route of Administration: Oral Composition: Each uncoated prolonged release tablet contains: Metformin Hydrochloride IP 1000 mg Excipients q.s. Mechanism of Action: Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Indications: Torformin 1000 SR is indicated for the treatment of patients with type II diabetes mellitus when diet, exercise and single agent does not result in adequate glycemic control. Dosage: As directed by the physician. Storage: Store at a temperature not exceeding 30°C, protected from light & moisture. Presentation: 20 x 10 Side effects: The following adverse reactions may occur: Lactic Acidosis Taste Disturbance Nausea Vomiting Diarrhoea Abdominal Pain Loss of Appetite Contraindications: Torformin 1000 SR is contraindicated in patients with: Known hypersensitivity to metformin or any of the components of this product. Severe renal impairment Acute conditions with the potential to alter renal function such as: - dehydration, - severe infection, - shock Disease which may cause tissue hypoxia Decompensated Heart Failure Respiratory Failure Recent Myocardial Infarction Shock Hepatic insufficiency, acute alcohol intoxication, alcoholism Drug Interactions: Alcohol NSAIDs ACE Inhibitors Angiotensin II Receptor Antagonists Diuretics Verapamil Rifampicin Cimetidine, Dolutegravir, Ranolazine, Trimethoprime, Isavuconazole, Vandetanib, Crizotinib, Olaparib