Description: Torliptin VM 1000 contains Vildagliptin, a member of the islet enhancer class, is a potent and selective DPP-4 inhibitor and Metformin, a biguanide with antihyperglycaemic effects, lowering both basal and postprandial plasma glucose. Pharmaceutical Dosage Form: Tablet Route of Administration: Oral Composition: Each film coated tablet contains: Vildagliptin IP 50 mg Metformin Hydrochloride IP 1000 mg Excipients q.s. Mechanism of Action: Vildagliptin results in a rapid and complete inhibition of DPP-4 activity, resulting in increased fasting and postprandial endogenous levels of the incretin hormones GLP1 (glucagon-like peptide 1) and GIP (glucose-dependent insulinotropic polypeptide). Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Indications: Torliptin VM 1000 is indicated for the treatment of patients with type II diabetes mellitus when diet, exercise and single agent does not result in adequate glycemic control. Dosage: As directed by the physician. Storage: Store protected from moisture, at a temperature not exceeding 30ºC. Presentation: 10 x 15 Side effects: The following adverse reactions may occur: Hypoglycaemia Tremor Headache dizziness Nausea Contraindications: Torliptin VM 1000 is contraindicated in patients with: Known hypersensitivity to Vildaglitin, Metformin or any of the components of this product. Any type of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis) Diabetic pre-coma Severe renal failure (GFR < 30 ml/min) Acute conditions with the potential to alter renal function, such as: dehydration severe infection shock intravascular administration of iodinated contrast agents. Acute or chronic disease which may cause tissue hypoxia, such as: cardiac or respiratory failure, recent myocardial infarction, shock Hepatic impairment Acute alcohol intoxication, alcoholism Breast-feeding Drug Interactions: Alcohol NSAIDs ACE Inhibitors Angiotensin II Receptor Antagonists Diuretics