Each 5ml contains:
Co-Trimoxazole is a mixture of Sulphamethoxazole and Trimethoprim. A potent synergy exists between its components with an increase of up to about 10-fold in anti-bacterial activity.
MECHANISM OF ACTION:
Sulfamethoxazole / Trimethoprim interferes with the bacterial synthesis of Tetrahydrofolic acid, an important stage in the production of thymidine, purines, and subsequently nucleic acids. Sulfamethoxazole inhibits the formation of dihydrofolic acid from p-aminobenzoic acid; Trimethoprim inhibits the action of the enzyme Dihydrofolatereductase, thus preventing the synthesis of tetrahydrofolic acid from dihydrofolic acid. Thus the combination of trimethoprim and sulfamethoxazole blocks two consecutive steps within the bacterial metabolic pathway of the biosynthesis of nucleic acids and proteins.
Indicated to treat ear infections, urinary tract infections, bronchitis, traveller’s diarrhea, and shigellosis.
It should not be given to patients with a history of Sulfonamides, Trimethoprim, or Sulfamethoxazole hypersensitivity. It should not be given during pregnancy and severe renal insufficiency.
Nausea, vomiting, diarrhea, and skin rashes can occur. These are reversible on withdrawal of the drug.
As directed by the physician.
- Store in a dry place below 25°C. Protect from light.
- Keep all medicines out of the reach of children.
- SHAKE WELL BEFORE USE