Albendazole is a benzimidazole drug, an anthelmintic used for the treatment of a variety of parasitic worm infestations.
Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.INDICATIONS:
Indicated for single or mixed infestation of gastrointestinal nematodes- Ascaris (roundworm), Trichuria (whipworm) and hookworms.
Contraindicated in pregnant and breastfeeding women, neonates, patients with known hypersensitivity, and liver impairment.
Nausea, vomiting, abdominal pain, or temporary hair loss.
As directed by the physician.
Keep away from heat and light.SHAKE WELL BEFORE USE
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