Amtorque AT Tablets

Description: Amtorque AT Tablets contain Amlodipine a calcium channel blocker, selective calcium channel blockers with mainly vascular effects and Atenolol, a beta-blocker which is beta1-selective, acts preferentially on beta1-adrenergic receptors in the heart. Pharmaceutical Dosage Form: Tablet Route of Administration: Oral Composition:

Mechanism of Action: The mechanism of the antihypertensive action of amlodipine is due to a direct relaxant effect on vascular smooth muscle. The precise mechanism by which amlodipine relieves angina has not been fully determined but amlodipine reduces total ischemic burden by the following two actions. Amlodipine dilates peripheral arterioles and thus, reduces the total peripheral resistance (afterload) against which the heart works. The mechanism of action of amlodipine also probably involves dilatation of the main coronary arteries and coronary arterioles, both in normal and ischemic regions. This dilatation increases myocardial oxygen delivery in patients with coronary artery spasm (Prinzmetal's or variant angina). Atenolol reduces cardiac rate and contractility which makes it effective in eliminating or reducing the symptoms of patients with angina. Indications: Amtorque AT Tablets are indicated for the treatment of mild to moderate hypertension and all grades of angina, unresponsive to Atenolol or Amlodipine monotherapy. Dosage: As directed by the physician. Storage: Store protected from light & moisture, at a temperature not exceeding 30°C. Presentation: 20 x 10 Tablets Side effects: Somnolence, Dizziness, Headache Visual Disturbance Palpitations, Flushing, Dyspnoea Abdominal Pain, Nausea, Dyspepsia, Altered Bowel Habits Ankle Swelling, Muscle Cramps Fatigue, Asthenia Contraindications: Amlodipine is contraindicated in patients with hypersensitivity to dihydropyridine derivatives, amlodipine, atenolol or to any of the excipients or to any of the excipients, Severe hypotension, Shock (including cardiogenic shock), Obstruction of the outflow tract of the left ventricle (e.g., high grade aortic stenosis), Haemodynamically unstable heart failure after acute myocardial infarction, uncontrolled heart failure, sick sinus syndrome, second-or third-degree heart block, untreated phaeochromocytoma, metabolic acidosis, bradycardia, hypotension and severe peripheral arterial circulatory disturbances. Drug Interactions: Amtorque AT Tablets can cause drug interaction with following drugs: Protease Inhibitors Azole Antifungals Macrolides Like Erythromycin or Clarithromycin Verapamil Diltiazem Rifampicin Dantrolene Tacrolimus Cyclosporine Simvastatin Nifedipine Adrenaline Insulin and Oral Antidiabetic Drugs Ibuprofen and Indomethacin Anaesthetic Agents