Product Description
Description: Threeclotrim Cream is a topical medication offering anti-inflammatory, antifungal, and antibacterial actions for the treatment of skin conditions involving inflammation, fungal infections, and bacterial complications.
Pharmaceutical Dosage Form: Cream
Route of Administration: Topical
Composition:
Betamethasone Dipropionate I.P.
to Betamethasone 0.05% w/w
Clotrimazole I.P. 1.0% w/w
Neomycin Sulphate I.P. 0.5% w/w
Cream Base q.s.
Mechanism of Action: Betamethasone dipropionate exerts its anti-inflammatory effects by binding to glucocorticoid receptors, inhibiting inflammatory mediator release, suppressing immune responses, and reducing edema, providing relief in various inflammatory skin conditions. Neomycin inhibits bacterial protein synthesis by binding to bacterial ribosomes. It exhibits broad-spectrum antibacterial activity, particularly against Gram-negative bacteria, aiding in the prevention and treatment of bacterial infections. Clotrimazole inhibits ergosterol synthesis, a crucial component of fungal cell membranes. It exhibits antifungal activity against a variety of fungi, disrupting their cell membrane integrity and preventing fungal growth.
Indications: Threeclotrim Cream is indicated for the relief of the inflammatory manifestations of corticosteroid response dermatoses when complicated by secondary bacterial & fungal infections.
Dosage: As directed by the physician.
Storage: Store below 30°C
Presentation: 15gm tube
Side effects:
Skin irritation
Thinning of skin
Burning
Itching
Redness
Contraindications: Patients with a history of hypersensitivity or allergic reactions to any of the components in the combination should avoid its use.
Precautions:
Concurrent use of multiple topical medications may increase the risk of skin irritation. Apply different topical products at different times.
Prolonged or extensive use of corticosteroids, such as betamethasone dipropionate, can lead to systemic absorption and potential corticosteroid-related side effects.
While clotrimazole is primarily used topically, systemic antifungal medications may interact with the antifungal component of the combination.