Chloramphenicol Palmitate is a dichloroacetic acid derivative. Chloramphenicol is a broad-spectrum antibiotic and is bacteriostatic. It contains 55.5-59.5% of chloramphenicol, i.e., approx. 174 mg of Chloramphenicol Palmitate is equivalent to 100 mg of Chloramphenicol.
Each 5ml contains:
Eq. to Chloramphenicol IP
In a flavoured syrupy base
MECHANISM OF ACTION:
Chloramphenicol is hydrolyzed in the upper intestinal tract into the parent drug. It is lipid-soluble, diffuses through the bacterial cell membrane, and reversibly binds to the 50 S subunit of bacterial ribosomes where transfer of amino acids to growing peptide chains is prevented, thus inhibiting peptide bond formation and subsequent protein synthesis.
It is effective against broad spectrum bacterial (gram-positive and gram-negative) diseases.
Chloramphenicol is contraindicated if another drug can be used instead due to its potential to cause bone marrow depression.
This medication may cause stomach upset, diarrhea, headache, nausea, and vomiting, which should disappear in a few days as your body adjusts to the medication.
Diabetes medicine, warfarin, phenytoin, phenobarbital, rifampin, other antibiotics, vitamin B12, iron, and folic acid. This drug may interfere with the effectiveness of birth control pills.
PRECAUTIONS & WARNING:
Blood dyscrasias may be associated with the use of chloramphenicol. Adequate blood studies must be made. Use extreme caution when giving this drug to children under two years old.
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As directed by the physician.
SHAKE WELL BEFORE USE
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