Torque's Glimtor MV2 Tablets

Description: Torque’s Glimtor MV2 Tablets contain Glimepiride, a sulphonylurea antihyperglycaemic agent acts mainly by stimulating insulin release from pancreatic beta cells, Metformin, a biguanide with antihyperglycaemic effects, lowering both basal and postprandial plasma glucose and Voglibose, an alpha glucosidase inhibitor. Pharmaceutical Dosage Form: Tablet Route of Administration: Oral Composition:

Mechanism of Action: Glimepiride primarily lowers blood glucose by stimulating the release of insulin from pancreatic beta-cells. It binds to the sulphonylurea receptor in the pancreatic beta-cell plasma membrane, leading to closure of the ATP-sensitive potassium channel, thereby stimulating the release of insulin. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Voglibose is an alpha glucosidase inhibitor which reduces intestinal absorption of starch, dextrin, and disaccharides by inhibiting the action of α-glucosidase in the intestinal brush border. Inhibition of this enzyme catalyzes the decomposition of disaccharides into monosaccharides and slows the digestion and absorption of carbohydrates; the postprandial rise in plasma glucose is blunted in both normal and diabetic subjects resulting in improvement of post prandial hyperglycemia and various disorders caused by hyperglycemia. Indications: Torque’s Glimtor MV2 Tablets indicated for the treatment of patients with type II diabetes mellitus when diet, exercise and single agent does not result in adequate glycemic control. Dosage: As directed by the physician. Storage: Store protected from light & moisture, at a temperature not exceeding 25ºC. Presentation: 10 x 15 Tablets Side effects: The following adverse reactions may occur: Lactic Acidosis Taste Disturbance Nausea, Vomiting, Diarrhoea, Abdominal Pain, Flatulence, Loss of Appetite Upper respiratory tract infection Anaemia Hypo-Glycaemia Hypo-Aesthesia Headache, Dizziness Arthralgia, Back Pain Haematuria Erectile Dysfunction Contraindications: Torque’s Glimtor MV2 Tablets contraindicated in patients with: Known hypersensitivity to metformin, glimepiride, voglibose or any of the components of this product. Severe renal impairment Acute or chronic metabolic acidosis, including diabetic ketoacidosis and lactic acidosis Diabetic pre-coma Patients with established NYHA class III or IV heart failure Acute or chronic disease which may cause tissue hypoxia such as cardiac or respiratory failure, recent myocardial infarction, shock Hepatic insufficiency, acute alcohol intoxication, alcoholism Acute conditions with the potential to alter renal function such as: - Dehydration - Severe infection - Shock - Intravascular administration of iodinated contrast agents Lactation Drug Interactions: Alcohol NSAIDs ACE Inhibitors Angiotensin II Receptor Antagonists Diuretics Verapamil Rifampicin Cimetidine, Dolutegravir, Ranolazine, Trimethoprime, Isavuconazole, Fluconazole Vandetanib, Crizotinib, Olaparib Thyroid Stimulating Agents, Glucocorticoids Anabolic Steroids and Male Sex Hormones Gemfibrozil